Prevalence and heritability of obsessive-compulsive spectrum and anxiety disorder symptoms: A survey of the Australian twin registry

C López-Solà; LF Fontenelle; P Alonso; D Cuadras; DL Foley; C Pantelis; J Pujol; M Yücel; N Cardoner; C Soriano-Mas; JM Menchón; BJ Harrison

Journal article

Prevalence and heritability of obsessive-compulsive spectrum and anxiety disorder symptoms: A survey of the Australian twin registry

C López-Solà, LF Fontenelle, P Alonso, D Cuadras, DL Foley, C Pantelis, J Pujol, M Yücel, N Cardoner, C Soriano-Mas, JM Menchón, BJ Harrison

American Journal of Medical Genetics Part B Neuropsychiatric Genetics | Published : 2014

DOI: 10.1002/ajmg.b.32233

Abstract

While past twin studies indicate moderate levels of heritability of "obsessive-compulsive related" and anxiety disorder symptoms, no single study has reported such estimates in the same twin population nor examined potential genetic sex differences. We assessed symptoms of obsessive-compulsive disorder, body dysmorphic disorder, hoarding disorder, hypochondriasis, panic disorder, social phobia and generalized anxiety disorder in 2,495 adult twins (1,468 female). Prevalence estimates for the corresponding symptom measures were determined using empirically derived cut-off scores. Twin resemblance was assessed by Pearson correlations and biometrical model-fitting analyses, incorporating sex-spe..

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University of Melbourne Researchers

Christos Pantelis Author

Ben Harrison Author

Related Projects (2)

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Specific Brain Networks Related to the Symptoms of Obsessive-Compulsive Disorder

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by Spanish Ministry of Education, Culture and Sport

Awarded by Carlos III Health Institute

Awarded by NHMRC

Funding Acknowledgements

Grant sponsor: Early Career Researcher Grant from The University of Melbourne; Grant sponsor: National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Fellowship; Grant number: 628509; Grant sponsor: Spanish Ministry of Education, Culture and Sport; Grant number: FPU12/01636; Grant sponsor: 'Miguel Servet' contract from the Carlos III Health Institute; Grant number: CP10/00604; Grant sponsor: NHMRC Senior Principal Research Fellowship; Grant number: 628386; Grant sponsor: NARSAD Distinguished Investigator Award; Grant sponsor: NHMRC Senior Research Fellowship; Grant number: 1021973.